Endocrine Abstracts

Aim: Re-analyzing (study starting in 2007) the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Materials and Methods: A. Patients: at onset 231 men with hypogonadism (median: 62 y). B. Distribution: by decade (starting with 20y); no =4, 14, 24, 61, 63, 49, 17, 1. C. TUD (NebidoR-Bayer) 1000 mg injected one/3 months i.m. D. Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5–5 MHz probe, ellip...

We present three cases of females with low body weight that needed large amounts of anti-thyroid drugs – 4–5 mg/kg Thiamazole and 50 mg/kg of Propylthiouracil. First patient, aged 32, weight 45 kg, had Graves’s disease evolving for more than five years. She has been proposed surgery and needed 1200 mg/day of Propylthiouracil. She delayed surgery for 2 weeks, then the dosage required for euthyroidism was 1800 mg/day for three weeks. The goitre had 1.2 kg, from ma...

A 1 month old baby boy presented at a local district general hospital with failure to thrive. He was born to non-consanguineous Eastern European parents, with an 18 month old healthy sister. The term birth was unremarkable, with nil of note from the antenatal history. Initial clinical examination revealed a slightly low but stable blood pressure for age, but was otherwise normal.Investigations: Biochemistry results showed low plasma sodium (125 mmol/l) a...

Introduction: Osteoporosis is a well-known and extremely debated side effect of glucocorticoid therapy being able to generate vertebral fractures even at low doses. Our study highlights the need for better prevention through improved doctor-patient communication and correct implementation of available screening tools.Methods: Since August–December 2014 we distributed to 85 rheumatic patients a self-compiled questionnaire. We recorded patient data an...

Introduction: Parathyroid adenomas are the main cause of primary hyperparathyroidism. They are usually small – weighing <1 g – and not easy to find – requiring meticulous imaging studies for localisation. Giant adenomas are uncommon; large tumours and high levels of PTH raise the suspicion of parathyroid malignancy.Case presentation: A 68-year-old female presented in our clinic with polydipsia, poliuria, nausea, weight loss, and extrem...

Introduction: Obesity prevalence is growing every year. In most cases, origin is exogenous, a mixture of sedentary and overeating. However, some patients are trend to develop obesity caused by their genetics and other illness.Case report: A 62-year-old women with diabetes type 2, anxiety and osteoporosis was remitted to our center for obesity. She had been obese since childhood, with very low level of activity and snacking trend. On physical examination ...

Aim: Most research teams analyze the evolution of patients with Hashimoto thyroiditis (HT) on syndromic basis (e.g., the thyroid function), not on pathogenic basis (the autoantibodies). Thus, most researchers refer to thyroid hormone evolution. In this study we re-analyzed (first in 2018) how evolve the antithyroid autoantibodies. Therefore, we analyzed the antithyroperoxydase antibodies (ATPO) evolutive patterns in patients with HT.Method: 1. ATPO level...

Aim: To find if testosterone undecanoat 1000 mg injection (Nebido; Bayer-Schering) has a negative effect on prostate.Materials and methods: i) PSA (ng/ml) was registred retrospective (from files) and prospective analysis (onset 2010). ii) From over 175 patients to whom testosterone undecanoate 1000 mg, i.m. was administrated at 3 months, in the last 4 years, and to whom the prostatic volume was quantified (Journal of Sexual Medicine8</st...

The aim of the study was to assess lipid status in subjects with hypothyroidism (overt and subclinical) and hyperthyroidism. Therefore, we analyzed the relationship between the levels of blood lipids (Lp(a), Apo AI, Apo B, Apo AI/B, total cholesterol (TC), triglyceride (TG), LDL, HDL, LDL) and TSH, FT4, T3, TPOAb concentration. The study groups included 38 subjects with overt hypothyroidism (mean±S.E.M., age 48.6±13.25 years), 30 ...

Graves’ thyrotoxicosis frequently occurs after delivery through immune rebound mechanism. A 34 years old patient, in postpartum period was referred to rheumatologist for gradually gait impairment. Examination showed only weakness of pelvic girdle muscles which required an extensive differential diagnosis including: neurological diseases and inflammatory/metabolic/toxic myopathies. Routine lab tests were unremarkable except low cholesterol (128 mg/dl) and slightly increase...